TRIB3 Back

tribbles homolog 3 (Drosophila)

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NCBI Description of TRIB3
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.

Community Annotation of TRIB3 Add / Edit TRIB3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TRIB3 is highly significantly mutated in
(none)
TRIB3 is significantly mutated in
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TRIB3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TRIB3