TREX1 Back

three prime repair exonuclease 1

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NCBI Description of TREX1
This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TREX1 is highly significantly mutated in
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TREX1 is significantly mutated in
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TREX1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TREX1