TREM2 Back

triggering receptor expressed on myeloid cells 2

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NCBI Description of TREM2
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of TREM2 Add / Edit TREM2: Annotations

No community annotations yet for TREM2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TREM2 is highly significantly mutated in
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TREM2 is significantly mutated in
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TREM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TREM2