TPP2 Back

tripeptidyl peptidase II

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NCBI Description of TPP2
This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class.

Community Annotation of TPP2 Add / Edit TPP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TPP2 is highly significantly mutated in
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TPP2 is significantly mutated in
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TPP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TPP2