TPM2 Back

tropomyosin 2 (beta)

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NCBI Description of TPM2
This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TPM2 Add / Edit TPM2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TPM2 is highly significantly mutated in
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TPM2 is significantly mutated in
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TPM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TPM2