TPBG Back

trophoblast glycoprotein

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NCBI Description of TPBG
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.

Community Annotation of TPBG Add / Edit TPBG: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TPBG is highly significantly mutated in
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TPBG is significantly mutated in
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TPBG is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TPBG