TP73 Back

tumor protein p73

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TP73

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined.

Community Annotation of TP73 Add / Edit TP73: Annotations

No community annotations yet for TP73.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TP73 is highly significantly mutated in
(none)
TP73 is significantly mutated in
(none)
TP73 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TP73