TP53BP2 Back

tumor protein p53 binding protein, 2

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NCBI Description of TP53BP2
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TP53BP2 Add / Edit TP53BP2: Annotations

No community annotations yet for TP53BP2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TP53BP2 is highly significantly mutated in
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TP53BP2 is significantly mutated in
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TP53BP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TP53BP2