TOX3 Back

TOX high mobility group box family member 3

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NCBI Description of TOX3
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TOX3 Add / Edit TOX3: Annotations

No community annotations yet for TOX3.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TOX3 is highly significantly mutated in
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TOX3 is significantly mutated in
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TOX3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TOX3