TOPORS Back

topoisomerase I binding, arginine/serine-rich

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NCBI Description of TOPORS
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.

Community Annotation of TOPORS Add / Edit TOPORS: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TOPORS is highly significantly mutated in
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TOPORS is significantly mutated in
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TOPORS is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TOPORS