TOPBP1 Back

topoisomerase (DNA) II binding protein 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TOPBP1
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.

Community Annotation of TOPBP1 Add / Edit TOPBP1: Annotations

No community annotations yet for TOPBP1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TOPBP1 is highly significantly mutated in
(none)
TOPBP1 is significantly mutated in
(none)
TOPBP1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TOPBP1