TOP3A Back

topoisomerase (DNA) III alpha

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NCBI Description of TOP3A
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TOP3A is highly significantly mutated in
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TOP3A is significantly mutated in
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TOP3A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TOP3A