TOLLIP Back

toll interacting protein

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NCBI Description of TOLLIP
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase.

Community Annotation of TOLLIP Add / Edit TOLLIP: Annotations

No community annotations yet for TOLLIP.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TOLLIP is highly significantly mutated in
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TOLLIP is significantly mutated in
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TOLLIP is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TOLLIP