TNS1 Back

tensin 1

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NCBI Description of TNS1
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and Northern Blot.

Community Annotation of TNS1 Add / Edit TNS1: Annotations

No community annotations yet for TNS1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNS1 is highly significantly mutated in
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TNS1 is significantly mutated in
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TNS1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNS1