TNIP1 Back

TNFAIP3 interacting protein 1

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NCBI Description of TNIP1
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TNIP1 Add / Edit TNIP1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNIP1 is highly significantly mutated in
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TNIP1 is significantly mutated in
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TNIP1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNIP1