TNFSF8 Back

tumor necrosis factor (ligand) superfamily, member 8

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TNFSF8
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TNFSF8 Add / Edit TNFSF8: Annotations

No community annotations yet for TNFSF8.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFSF8 is highly significantly mutated in
(none)
TNFSF8 is significantly mutated in
(none)
TNFSF8 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFSF8