TNFSF12 Back

tumor necrosis factor (ligand) superfamily, member 12

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TNFSF12
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Community Annotation of TNFSF12 Add / Edit TNFSF12: Annotations

No community annotations yet for TNFSF12.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFSF12 is highly significantly mutated in
(none)
TNFSF12 is significantly mutated in
(none)
TNFSF12 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFSF12