TNFRSF9 Back

tumor necrosis factor receptor superfamily, member 9

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NCBI Description of TNFRSF9

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of TNFRSF9 Add / Edit TNFRSF9: Annotations

No community annotations yet for TNFRSF9.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF9 is highly significantly mutated in
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TNFRSF9 is significantly mutated in
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TNFRSF9 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TNFRSF9