TNFRSF6B Back

tumor necrosis factor receptor superfamily, member 6b, decoy

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NCBI Description of TNFRSF6B
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF6B is highly significantly mutated in
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TNFRSF6B is significantly mutated in
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TNFRSF6B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFRSF6B