NCBI Description of TNFRSF4
|The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.|
Community Annotation of TNFRSF4 Add / Edit TNFRSF4: Annotations
No community annotations yet for TNFRSF4.
Click on a tumor type to see its full list of significant genes.