TNFRSF4 Back

tumor necrosis factor receptor superfamily, member 4

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NCBI Description of TNFRSF4
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF4 is highly significantly mutated in
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TNFRSF4 is significantly mutated in
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TNFRSF4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFRSF4