TNFRSF21 Back

tumor necrosis factor receptor superfamily, member 21

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NCBI Description of TNFRSF21
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF21 is highly significantly mutated in
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TNFRSF21 is significantly mutated in
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TNFRSF21 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFRSF21