TNFRSF19 Back

tumor necrosis factor receptor superfamily, member 19

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NCBI Description of TNFRSF19
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Community Annotation of TNFRSF19 Add / Edit TNFRSF19: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF19 is highly significantly mutated in
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TNFRSF19 is significantly mutated in
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TNFRSF19 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFRSF19