TNFRSF18 Back

tumor necrosis factor receptor superfamily, member 18

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NCBI Description of TNFRSF18

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF18 is highly significantly mutated in
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TNFRSF18 is significantly mutated in
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TNFRSF18 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TNFRSF18