TNFRSF13B Back

tumor necrosis factor receptor superfamily, member 13B

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NCBI Description of TNFRSF13B
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF13B is highly significantly mutated in
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TNFRSF13B is significantly mutated in
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TNFRSF13B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFRSF13B