TNFRSF11B Back

tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

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NCBI Description of TNFRSF11B
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF11B is highly significantly mutated in
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TNFRSF11B is significantly mutated in
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TNFRSF11B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFRSF11B