TNFRSF11A Back

tumor necrosis factor receptor superfamily, member 11a, NFKB activator

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NCBI Description of TNFRSF11A
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TNFRSF11A is highly significantly mutated in
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TNFRSF11A is significantly mutated in
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TNFRSF11A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TNFRSF11A