TMPRSS4 Back

transmembrane protease, serine 4

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NCBI Description of TMPRSS4
This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TMPRSS4 is highly significantly mutated in
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TMPRSS4 is significantly mutated in
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TMPRSS4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TMPRSS4