TMPRSS15 Back

transmembrane protease, serine 15

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NCBI Description of TMPRSS15
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TMPRSS15 is highly significantly mutated in
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TMPRSS15 is significantly mutated in
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TMPRSS15 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TMPRSS15