TMEM189-UBE2V1 Back

TMEM189-UBE2V1

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NCBI Description of TMEM189-UBE2V1
The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and on experimental data in PMID:11076860.

Community Annotation of TMEM189-UBE2V1 Add / Edit TMEM189-UBE2V1: Annotations

No community annotations yet for TMEM189-UBE2V1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TMEM189-UBE2V1 is highly significantly mutated in
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TMEM189-UBE2V1 is significantly mutated in
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TMEM189-UBE2V1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TMEM189-UBE2V1