TMEM185A Back

transmembrane protein 185A

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TMEM185A
The protein encoded by this gene is predicted to be a transmembrane protein, but this has not been experimentally determined. This gene is better known for localizing to the CpG island of the fragile site FRAXF. The 5-prime untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TMEM185A Add / Edit TMEM185A: Annotations

No community annotations yet for TMEM185A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TMEM185A is highly significantly mutated in
(none)
TMEM185A is significantly mutated in
(none)
TMEM185A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TMEM185A