TMEM127 Back

transmembrane protein 127

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NCBI Description of TMEM127
This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified.

Community Annotation of TMEM127 Add / Edit TMEM127: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TMEM127 is highly significantly mutated in
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TMEM127 is significantly mutated in
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TMEM127 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TMEM127