TMC1 Back

transmembrane channel-like 1

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NCBI Description of TMC1

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness.

Community Annotation of TMC1 Add / Edit TMC1: Annotations

No community annotations yet for TMC1.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TMC1 is highly significantly mutated in
TMC1 is significantly mutated in
TMC1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TMC1