TM4SF1 Back

transmembrane 4 L six family member 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TM4SF1

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.

Community Annotation of TM4SF1 Add / Edit TM4SF1: Annotations

No community annotations yet for TM4SF1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TM4SF1 is highly significantly mutated in
TM4SF1 is significantly mutated in
TM4SF1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TM4SF1