TM2D2 Back

TM2 domain containing 2

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NCBI Description of TM2D2

The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms.

Community Annotation of TM2D2 Add / Edit TM2D2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TM2D2 is highly significantly mutated in
TM2D2 is significantly mutated in
TM2D2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TM2D2