TM2D1 Back

TM2 domain containing 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TM2D1

The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death.

Community Annotation of TM2D1 Add / Edit TM2D1: Annotations

No community annotations yet for TM2D1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TM2D1 is highly significantly mutated in
TM2D1 is significantly mutated in
TM2D1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TM2D1