TLX2 Back

T-cell leukemia homeobox 2

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NCBI Description of TLX2

This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors.

Community Annotation of TLX2 Add / Edit TLX2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


TLX2 is highly significantly mutated in
TLX2 is significantly mutated in
TLX2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for TLX2