TLX1 Back

T-cell leukemia homeobox 1

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NCBI Description of TLX1

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants.

Community Annotation of TLX1 Add / Edit TLX1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TLX1 is highly significantly mutated in
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TLX1 is significantly mutated in
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TLX1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TLX1