TLK1 Back

tousled-like kinase 1

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NCBI Description of TLK1
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.

Community Annotation of TLK1 Add / Edit TLK1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TLK1 is highly significantly mutated in
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TLK1 is significantly mutated in
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TLK1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TLK1