TIMP2 Back

TIMP metallopeptidase inhibitor 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of TIMP2
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Community Annotation of TIMP2 Add / Edit TIMP2: Annotations

No community annotations yet for TIMP2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TIMP2 is highly significantly mutated in
(none)
TIMP2 is significantly mutated in
(none)
TIMP2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TIMP2