TIMM8B Back

translocase of inner mitochondrial membrane 8 homolog B (yeast)

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NCBI Description of TIMM8B
This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TIMM8B is highly significantly mutated in
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TIMM8B is significantly mutated in
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TIMM8B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TIMM8B