TIE1 Back

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

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NCBI Description of TIE1

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of TIE1 Add / Edit TIE1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TIE1 is highly significantly mutated in
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TIE1 is significantly mutated in
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TIE1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TIE1