TIAM2 Back

T-cell lymphoma invasion and metastasis 2

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NCBI Description of TIAM2
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.

Community Annotation of TIAM2 Add / Edit TIAM2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TIAM2 is highly significantly mutated in
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TIAM2 is significantly mutated in
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TIAM2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TIAM2