TIAL1 Back

TIA1 cytotoxic granule-associated RNA binding protein-like 1

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NCBI Description of TIAL1
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing.

Community Annotation of TIAL1 Add / Edit TIAL1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TIAL1 is highly significantly mutated in
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TIAL1 is significantly mutated in
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TIAL1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TIAL1