THPO Back

thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)

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NCBI Description of THPO
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.

Community Annotation of THPO Add / Edit THPO: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

THPO is highly significantly mutated in
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THPO is significantly mutated in
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THPO is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for THPO