THNSL2 Back

threonine synthase-like 2 (S. cerevisiae)

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NCBI Description of THNSL2
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

THNSL2 is highly significantly mutated in
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THNSL2 is significantly mutated in
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THNSL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for THNSL2