THEMIS Back

thymocyte selection associated

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NCBI Description of THEMIS

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

THEMIS is highly significantly mutated in
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THEMIS is significantly mutated in
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THEMIS is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for THEMIS