THEM4 Back

thioesterase superfamily member 4

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NCBI Description of THEM4

Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas.

Community Annotation of THEM4 Add / Edit THEM4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


THEM4 is highly significantly mutated in
THEM4 is significantly mutated in
THEM4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for THEM4