THAP1 Back

THAP domain containing, apoptosis associated protein 1

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NCBI Description of THAP1

The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


THAP1 is highly significantly mutated in
THAP1 is significantly mutated in
THAP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for THAP1