TGM5 Back

transglutaminase 5

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NCBI Description of TGM5

This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome.

Community Annotation of TGM5 Add / Edit TGM5: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TGM5 is highly significantly mutated in
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TGM5 is significantly mutated in
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TGM5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for TGM5