TGM3 Back

transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)

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NCBI Description of TGM3
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.

Community Annotation of TGM3 Add / Edit TGM3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

TGM3 is highly significantly mutated in
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TGM3 is significantly mutated in
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TGM3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for TGM3